Diffuse Pruritis — Differential Diagnosis
Skin Lesions Noted |
No Rash or Lesions
|
SUMMARY APPROACH — Itching WITH Rash
[see below for Itching W/O Rash]
1. If the rash comes & goes, it’ll be Urticaria (even if you don’t see it at the visit)- If lesions are present, you see wheals (hives)
- Maybe you just see erythematous flares
- Bilateral (often symmetric) scales or vesicles → Atopic Dermatitis (Eczema)
- Annular macules / patches with leading edge → T. corporis (Ringworm)
- Yellowish-tan / Reddish-tan plaques with extreme recalcitrant symptoms, consider cutaneous Mastocytosis (Rare!!! Send to Derm to confirm)
- Spreading contiguously from pubis → Pubic Lice (seek nits & maculae ceruleae)
- Homeless? Check seams of clothes for Body Lice
- Exposed areas only? Probably Bug Bites (papules-in-a-row = Bedbugs)
- Follicular pattern (inflamed hair follicles) → Folliculitis (common!!!)
- Sex / close contact 3 weeks prior to onset, or others in house infested
- Lesions on fingers & in webs, flexor creases of wrists
- Burrows are pathognomonic (but often absent)
- Virtually always on genitals, buttocks, near areolas (women)
- NOT on back or face
- Consider transparent tape microscopy (see last picture)
- Can offer therapeutic trial
SUMMARY APPROACH — Itching WITHOUT Rash
1. Test for Dermatographism (stroke small area with tongue blade).
- If a hive, even just itching, develops, treat with an H1 Blocker (loratadine, etc).
- Proximal muscle weakness, violacious rash (face or hands) → ESR, ANA, Muscle Enzymes (CK, AST, LDH, Aldolase) for Dermatomyositis & refer to Rheum
- Raynaud’s, arthralgias, skin changes of scleroderma → ANA for Scleroderma & refer to Rheum
- Suspicious nodes → biopsy for Lymphoma
- Splenomegaly → CBC, Abdominal CT for Lymphoma
- Dry Skin → TSH; therapeutic trial of emollients
- Disordered thinking, obsessions → refer to Psych (also r/o meth abuse)
- Empiric H1 Blocker (loratadine, etc). If no help, try doxepin.
- Seek possible causes from common allergens (consider avoidance trial)
If pruritis persists…….
4. Basic Labs: CBC, Comprehensive Metabolic Panel, TSH, ESR. Chest X-ray.- Seek Dx of Uremia, Hematologic Malignancy, Hyperthyroidism
- If ↑ Alk. Phos. → Antimitochondrial Ab for Primary Biliary Cirrhosis
- ↑ Globulin → SPEP for Multiple Myeloma
- ESR very high → consider Multiple Myeloma, Dermatomyositis. Consider chest & abdominal CTs for Lymphoma
- Chest X-ray: seek adenopathy for Lymphoma
- Continue to follow for B-symptoms or lymphadenopathy (if they occur, repeat labs & get pan-CT)
.