Medications / Drugs / Toxins (as cause of H/A)

Main culprits for “medication overuse syndrome” seem to be opioids, combination products with the barbiturate butalbital (e.g. Fiorinal®), those with aspirin + acetaminophen + caffeine, and triptans.  NSAIDs aren’t common but have also been implicated.  Consider this diagnosis if a single headache medication is taken over 10 days per month, or if various meds are mixed for over 15 days.

Substances can cause headache during use, or during withdrawal.  Obtaining a good chronology is the key here.

See posting Acute Headache – 4.