- Onset usually 30 – 50 y.o. Women affected more than men
Early Signs / Symptoms
Fatigue, Myalgias, Arthralgias
Skin Changes (esp. fingers, hands, face): [see Pix below]- Edema / Erythema / Pruritis
- Eventual thickening / hardening of skin
Raynaud Phenomenon
Possible Overall Manifestations- Soft tissue calcifications
- Digital Ulcers
- Pitting of fingertips
- Telangiectasias
- Chronic Esophageal Symptoms
- Interstitial Lung findings on CXR
- Abnormal renal function
Labs: Anti-Nuclear antibodies (ANA) usually elevated
Diagnosis — Obtain specific Antibodies:- Anti-Centromere
- Anti-Topoisomerase 1 (SCL 70)
See posting Polyarthralgias.
Skin Changes in Scleroderma