Mononucleosis

Key Symptom:  Fatigue

Signs:
  • Generalized Adenopathy (posterior cervical, occipital, axillary, epitrochlear)
  • Splenomegaly highly suggestive, but not so common
Lab:  Sensitive but not Specific:
  • CBC w/ manual differential for “Atypical Lymphocytes”
  • ALT & AST  (sensitive, tho not specific)
Monospot Test (Heterophile Agglutination): ±99% specific
  • May not seroconvert for 3-4 weeks
  • Possible false-positive with Primary HIV
  • Epstein-Barr IgM Ab more sensitive sooner, 100% specific

See posting Sore Throat – 2.

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